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Despite these observational studies, the prospective, blinded, and placebo-controlled VISP, NORVIT, HOPE-2, WAFACS, VITATOPS, and SEARCH trials have all failed to show a significant benefit of high-dose B vitamin (including cobalamin) supplementation for preventing thrombotic vascular events or death (254
Reduced frequency still provides benefits while minimizing injection burden
Weight-loss drugs like semaglutide may melt fat, but at the cost of muscle mass
Ethanol metabolism plays a significant role in ALD pathogenesis
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