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A side effect is an unwanted reaction that can occur during use (e.g., temporary nausea or a headache), which is often manageable by adjusting the dose and is not a pre-existing barrier to use
Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and pregnancy avoidance (with a 2-month washout period before conception)
In another mouse study, addition of 5% butyrate to HFD increased energy expenditure, improved insulin sensitivity, and induced adaptive thermogenesis in BAT followed by increased AMPK activity and mitochondrial biogenesis in muscle cells (66)
This study aims to fill this gap by addressing two key questions: how do buses respond dynamically to extreme conditions, and how can their planning and governance frameworks be optimized to enhance resilience
