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[72] reported high fasting glucose and low insulin sensitivity during the luteal phase, yet this finding was not significant
Its a reflection of pharmacology, not personal failure
They have been shown to decrease the risk of CKD, as well as slowing the progression to end-stage kidney disease in people with a reduced eGFR and macroalbuminuria
Patients are encouraged to report suspected adverse reactions to tirzepatide via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)
Putative mechanisms of tirzepatide-mediated nephroprotection The pathogenesis of CKD in patients with T2D likely involves other potential contributors besides hyperglycemia, such as hypertension, dyslipidemia, obesity, insulin resistance, glomerular atherosclerosis, renal ischemia, and nephron aging [53]
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