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Thyroid C-Cell Tumors: In mice and rats, tirzepatide (the active ingredient in Zepbound and Mounjaro) caused an increase in thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)
With that regulatory brake reduced, IGF-1 LR3 interacts with IGF-1 receptors more directly and for a longer duration, which is why research protocols report a half-life of roughly 2030 hours, compared to native IGF-1s 1215 hours
While the recommended daily dose of creatine consumed in the form of a supplement is 3-5g
However, any claims that IGF-1 can promote weight loss are largely theoretical, or based on animal studies and small human studies (14)
The cells were extensively washed 5-10 times with 50 mL of PBS to remove residual SLO and lysed RBC material
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