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The reason for gradually increasing dosages, per Alan, is to lower the risk of side effects

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The eye-opening study The study examined reports from nine individualsfive women and four menwith an average age of 58 who were taking semaglutide (the active ingredient in Ozempic and Wegovy) or tirzepatide (found in Mounjaro and Zepbound)

The use of nalbuphine, a blocker of - and -opioid receptors, also disrupted the effect of GLP-1RAs on reducing TNF- levels, highlighting the essential role of these opioid receptors in the anti-inflammatory effects mediated by GLP-1RAs.423 Furthermore, the study emphasized that neurons in specific brain regions, such as the hindbrain and hypothalamus, co-express GLP-1R along with 1-adrenergic and -opioid receptors, suggesting a localized mechanism within the CNS that could coordinate peripheral anti-inflammatory responses

Over one trial period, only a few participants (5.3%) discontinued treatment because of adverse events and those who continued treatment beyond 20 weeks were unlikely to experience significant problems thereafter