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6e, all three GSSG-enhancing chemicals increased the levels of IKK--SSG adducts, suggesting that GSSG accumulation restrained IKK- activity by promoting IKK- S -glutathionylation, leading to subsequent NF-B suppression

It offers significant advantages in enhancing drug targeting, achieving controlled release, and improving overall bioavailability

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Dose escalation periods: When increasing from 0.25 mg to 0.5 mg (typically after 4 weeks), and subsequently to 1 mg or 2 mg if required, patients may experience a temporary resurgence of digestive symptoms

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