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For this reason, propagated cell death should ideally be supported by multiple orthogonal criteria, including iron dependence, rescue by structurally distinct ferroptosis inhibitors, and preservation of canonical molecular hallmarks of ferroptosis

Shaobo Ding, [email protected] These authors have contributed equally to this work This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Furthermore, there is a complex relationship between weight loss and the hypothalamic-pituitary-thyroid axis