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Offlabel investigations include polymorphic light eruption (PLE), solar urticaria (SU), vitiligo (as adjunct to NBUVB), and xeroderma pigmentosum (XP)
LHCGR engagement activates Gs-coupled adenylyl cyclase, driving cAMP accumulation and PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD
Clinical studies have shown that patients treated with GLP-1 receptor agonists not only experience significant weight loss but also improvements in associated health markers, such as blood pressure and lipid profiles
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