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As the GP activity was previously studied only in tissues such as rat liver and placenta without optimization of substrata conditions [7], the selection of blood as the target compartment to study the effect of systemic peroxide levels has the advantage of investigating the compartment subjected to all the comprehensive effects of peroxide systemic accumulation
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The effect is usually indirect, caused by fatigue from caloric restriction, GI discomfort, or hormonal shifts from rapid weight loss
Therefore, it was removed in the sensitivity analysis to assess the stability of the overall findings and evaluate potential outlier effects
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