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974-977 Esposito, P., et al., 2003

Melanoma Types Melanoma typically falls into one of the following three types: Cutaneous melanoma Mucosal melanoma Ocular melanoma Cutaneous Melanoma There are four major types of cutaneous melanoma: Superficial spreading melanoma: Most common melanoma type About 70% of cases Usually starts in a pre-existing mole Nodular melanoma: Second most common melanoma type 15% to 30% of cases More aggressive and usually develops quicker than superficial spreading melanomas Lentigo maligna melanoma: Appears as large, flat lesions Most commonly found on the faces of light-skinned women over 50 4% to 10% of cases Lower risk of spreading than other melanoma types Acral lentiginous melanoma: Occurs on the palms, soles of the feet or beneath the nail beds 2% to 8% of melanomas in fair-skinned patients Up to 60% of melanomas in darker-skinned patients Large, with an average diameter of 3 centimeters Mucosal Melanoma About 1% of melanoma cases Occurs in mucosal tissue, which lines body cavities and hollow organs Most common sites are head and neck region (including the nasal cavity, mouth and esophagus), rectum, urinary tract and vagina Can be very difficult to detect Even when diagnosed and treated, prognosis is often poor Ocular Melanoma Because the eyes contain melanocytes, they can be susceptible to melanoma

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Cardiovascular markers Across dose cohorts, retatrutide treatment was associated with improvements in multiple cardiovascular risk factors including reductions in waist circumference, blood pressure, and triglyceride levels, with increases in HDL cholesterol

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