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Reduced caloric intake means less available energy

It typically peaks during the first one to two weeks at each new dose level and gradually diminishes as the body adapts

Animal studies indicate fetal growth restriction, ossification delay, skeletal variants, and reduced maternal weight gain, though more recent human evidence, including a 2024 cohort of 938 pregnancies, suggests no increased risk of major congenital malformations compared with insulin

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doi: 10.1523/JNEUROSCI.3632-07.2008 203 WangX