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Cosmelan is a permanent solution to lightening the appearance of hyperpigmentation associated with melasma and PIH, as long as strict sun avoidance is maintained after the treatment
Folinic acid, under the drug name leucovorin, a form of folate (formyl-THF), can help "rescue" or reverse the toxic effects of methotrexate
Glutathione is not advised to patients prone to asthma problems
It oxidises when exposed to air and light
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