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Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure

IGF-1 Elevation Increased HGH stimulates the liver to produce IGF-1, the downstream mediator responsible for many of growth hormone's tissue-level effects

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Monitoring plan : Agree on a structured monitoring schedule, including frequency of blood glucose checks, timing of follow-up appointments, and when to have repeat blood tests (such as HbA1c, renal function, liver function tests, and vitamin B12 levels for long-term metformin users)