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Given that obesity is a chronic and relapsing disease, it is important to understand the effectiveness of different strategies to maintain WL: TRIUMPH-6 (NCT06859268) will assess changes in bodyweight at 116 weeks in individuals with obesity who have completed 80 weeks of retatrutide, comparing continued treatment at high or low doses of retatrutide versus switching to placebo for the last 36 weeks
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By contrast, amiloride (1 mM), a pharmacological inhibitor of macropinocytosis (34), clearly inhibited cellular internalization of FAM(2836) (Supplemental Figure 6, E and F)
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