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The first of its kind initiative will uncover the biological mechanisms that determine individual variation in response to GLP-1s and find biomarkers associated with their safety, efficacy, and tolerability

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2) with or without obesity (79), acromegaly (80), before and after gastric bypass surgeries (79), and in totally pancreatectomized patients (81)

Abbreviations ADA: American Diabetes Association AE: Adverse event ASCVD: Atherosclerotic cardiovascular disease CI: Confidence interval CKD: Chronic kidney disease CVOT: Cardiovascular outcomes trial EASD: European Association for the Study of Diabetes eGFR: Estimated glomerular filtration rate GLP-1RA: Glucagon-like peptide-1 receptor agonist HbA1c: Hemoglobin A1c HF: Heart failure HHF: Hospitalization for heart failure HR: Hazard ratio MACE: Major adverse cardiovascular events OR: Odds ratio RCT: Randomized controlled trial RR: Relative risk SBP: Systolic blood pressure SGLT2i: Sodium-glucose cotransporter-2 inhibitor T2DM: Type 2 diabetes mellitus References Daz-Trastoy O, Villar-Taibo R, Sifontes-Dubn M, Mozo-Pealver H, Bernabeu-Morn I, Cabezas-Agrcola JM, et al

FDA approves new drug treatment for chronic weight management [Press release]