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It is this ratio, in particular, that distinguishes retatrutide from other triple agonists in development (such as survodutide, currently in Phase 3 trials at Boehringer)
Thats the key qualifier: used appropriately
Robust, compelling evidence: In the Phase 3 ESSENCE trial (Part 1), 63% of patients receiving Wegovy achieved resolution of steatohepatitis without worsening fibrosis, compared with 34% on placebo
Diuretic: This is the key part for our discussion
Front Pharmacol 9(9):176 Qian Y, Chen C, Ma L, Wang Z, Wang LF, Zuo L, Yang Y, Huang X, Jiang M, Wang X, Shi H (2018) CD38 deficiency promotes inflammatory response through activating Sirt1/NF-B-mediated inhibition of TLR2 expression in macrophages
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