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Reductions in alcohol and substance use GLP-1 medications were associated with decreased alcohol consumption and reduced substance use in several studies from this 2024 review
(2026), "Glucagon-Like Peptide-1 Receptor Agonists and Risk of Substance Use Disorders Among US Veterans With Type 2 Diabetes," BMJ , March 2026
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Notably, this protective effect occurred through mechanisms independent of changes in muscle oxidative metabolism or fatigue resistance, distinguishing IGF-1 LR3's mechanism from native IGF-1
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