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The most plausible explanation to why the endogenous levels of GLP-1 were unchanged in the study 18 was that the pharmacological GLP-1 RA stimulates GLP-1 receptors in the central nervous system andreduces appetite and slows down gastric emptying, giving all the desired effects of weight loss and lowered fasting glucose irrespective of the plasma concentrations of GLP-1 and glucagon

Calcium Channel Blockers (CCBs) Mechanism: Block L-type calcium channels vascular smooth muscle relaxation peripheral resistance Types & Examples: Dihydropyridines: Amlodipine, Nifedipine more vasodilatory Non-dihydropyridines: Verapamil, Diltiazem also heart rate Key Points: Good for isolated systolic hypertension, angina 4

Gels were subsequently stained by Instant Blue (Expedeon)

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