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4 mg to MTD)
The researchers found that GLP-1 receptor agonist initiation was associated with a reduced risk for disorders related to alcohol use, cannabis use, cocaine use, nicotine use, opioid use, and other SUDs compared with initiation of SGLT-2 inhibitors (hazard ratios, 0.82, 0.86, 0.80, 0.80, 0.75, and 0.87, respectively) and with a reduced risk for the composite outcome of all incident SUDs (hazard ratio, 0.86)
While other cardiovascular markers like blood pressure and lipids still trend in the right direction, that higher pulse is a specific signature we do not see as much with dual agonists
Imaging confirmed localization to lipid-rich inflamed regions, enabling simultaneous assessment of receptor expression and therapeutic delivery
The post treats persistent constipation as needing active management
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