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Research, including the STEP (Semaglutide Treatment Effect in People with obesity) clinical trials, has analyzed thousands of participants with overweight or obesity who also had prediabetes

These medicines include semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Victoza, Saxenda), dulaglutide (Trulicity), and tirzepatide (Mounjaro), which is a dual GIP/GLP-1 receptor agonist rather than a pure GLP-1 agonist

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Most existing comparisons of oral vs injectable semaglutide come from real-world observational studies of Rybelsus and Ozempic

Patients with a history of Multiple Endocrine Neoplasia syndrome type 2 are also advised against using this medication