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doi: 10.1007/s11523-017-0514-5 164 LarssonSCCarterPVithayathilMKarSMasonAMBurgessS

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Chronic hyperglycemia, elevated glycated hemoglobin (HbA1c) levels, and dyslipidemia, particularly characterized by increased triglycerides and low-density lipoprotein cholesterol, are independent risk factors that directly accelerate eGFR decline and progression to end-stage kidney disease (ESRD) (3, 5)

7 Recent advances and clinical trials for neurodegenerative diseases 7.1 NP-based siRNA delivery for ADs The instability of siRNA therapy in the circulation and the fact that it is unable to reach target cells in the central nervous system (91, 92) because of the BBB poses the biggest hurdle in siRNA therapy
