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Statistical analysis The data were analyzed using GraphPad Prism software (version 8.0.2, GraphPad Software, San Diego, California, USA)

Lipid ROS levels ( a ), cell viability ( e ), and colony number ( g, h ) were measured

Beauty starts at the cellular level

Immunohistochemical analysis revealed that TRAIL and BPTES synergistically decreased the tumor weight (Fig

These include: Large disc extrusions or sequestered fragments requiring surgical intervention Severe spinal stenosis with significant canal narrowing Bone spurs (osteophytes) compressing nerve structures Advanced degenerative disc disease with complete disc height loss Spondylolisthesis (vertebral slippage) beyond grade 1 Cauda equina syndrome (medical emergency requiring immediate surgery) Users with these conditions typically report minimal improvement from peptide therapy alone