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Under deep anaesthesia half of the animals were then perfused with ~ 5 ml PBS followed by 4% PFA, brain and spinal cord were collected for IHC analysis

Upon detection of dietary nutrients in the gut, GLP-1 is released from the intestinal L cells and binds to its receptor

The gradual titration is designed to allow the body to adjust to GLP-1 receptor activation and minimize gastrointestinal side effects during the initial treatment period

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