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Studies have shown that GLP-1R agonists not only promote insulin secretion and exert glucose-lowering effects but also effectively delay gastric emptying, reduce intestinal motility, activate neural pathways in the hypothalamus and appetite regulation areas, resulting in decreased appetite and reduced food intake, thus treating obesity

Tirzepatide was removed from the shortage list in December 2024

Some practitioners advocate for slower titration schedules, keeping patients on lower doses for longer periods before escalating

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