En outre, la production de TMA dans le clon dpend de la composition du microbiote (l'ensemble des micro-organismes bactries, virus, parasites et champignons non pathognes qui vivent dans le corps), variable dun individu lautre 17
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This metabolic byproduct also downregulates antigen-presenting capacity, ultimately compromising the ability of DCs to initiate effective T-cell responses (139)
Livak KJ, Schmittgen TD
Various biological mechanisms, including infection, inflammation, oxidative stress, immune system dysfunction, blood coagulation abnormalities, endothelial dysfunction, tissue damage, and cell death or apoptosis, are present at the tissue, cellular, and molecular levels, leading to a widespread and harmful systemic response