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Hot flushes may occur indirectly through weight loss-related hormonal changes, metabolic shifts, or glycaemic fluctuations rather than direct pharmacological action

Cancer Cell 36 , 319336.e7 (2019)

In the absence of validated protein, metabolite or genetic markers in CSF or blood, identifying patients most likely to benefit from ferroptosis-targeting therapies, assessing the treatment response or dose adjustment are difficult (9)