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While Tirzepatide is currently setting the bar when it comes to weight loss, Retatrutide is testing how high it can go

Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

And this fits that theme or the knowledge that we know of slower dose titration schemes works better in the long run

Do not start, stop, switch, or change the dose of a GLP-1 medication without guidance from the healthcare professional managing your treatment

[1] [3] Additionally, Ozempic slows gastric emptying, which helps to moderate post-prandial glucose spikes and promotes satiety, often leading to weight lossa beneficial effect for many patients with type 2 diabetes