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Conversely, in women with polycystic ovary syndrome (PCOS) , weight loss can actually improve menstrual regularity by reducing insulin resistance and androgen excess

GLP-1RAs, particularly liraglutide, can modulate this pathway in disease-specific contexts: In neonatal hypoxic-ischemic brain injury models, liraglutide activates PI3K/Akt signaling, reducing neuronal apoptosis and improving long-term cognitive outcomes (Zeng et al., 2019