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Gonadotrophin releasing hormone improves cognition in a mouse model of Down syndrome and has shown beneficial effects on cognition and connectivity in a preliminary trial of adults with Down syndrome likely due to A pathology [111]
It was limited by the lack of conclusive reports detailing the reaction, lack of re-administration, lack of toxic levels detected, and the potential for an unknown alternative diagnosis to be the source of the reaction
Cureus 15 (4), e38267
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