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10.1056/NEJMra1905136 N Engl J Med

7,77 Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in which one or more of the following occur due to the loss of proper regulation by the kidneys: Abnormal bone mineralization, strength, growth, and turnover Calcification of non-bone tissues, including blood vessels Irregularities in vitamin D, calcium, phosphorus, fibroblast growth factor-23, and parathyroid hormone metabolism Each of these abnormalities is associated with a high risk of mortality, primarily attributable to the cardiovascular consequences

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Current Pharmaceutical Design, 20(7), 1126-1135

this drug has recently completed phase 2a clinical trials with promising results in reducing HbA1c without any nausea [50]