Frequency depends on your goals and health status
People who drink a lot on a regular basis are more likely to have the CYP2E1 enzyme constantly upregulated, potentially increasing the conversion of acetaminophen into the toxic metabolite, NAPQI
Additionally, recent studies from 2024 to 2025 on NGPs highlight the urgent requirement for clearer guidance and harmonized approval procedures (156, 539)
And certainly, again, you know, with sensitivity of the nervous system, you know, catecholamines and potentially SNPs and COMT and other things, it can really get away from someone pretty quickly
Zhong G, Qin S, Townsend D, Schulte BA, Tew KD, Wang GY