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Notably, we found that the HR domain in ACTL6A was essential for regulating GCLC expression
10.5009/gnl18490 67 SikiricP.DrmicD.SeverM.KlicekR.BlagaicA
Layering on requirements for optimal pharmacological profiles and drug-like properties to support oral dosing adds another level of complexity. But acording to Terry Kenakin, a former GSK drug developer now at the University of North Carolina-Chapel Hill in the US, we are in what I call a renaissance in terms of finding compounds that modify the function of these [GPCR receptors]
doi: 10.1038/s41580-020-00314-w 216 LiXZhangZZhangYCaoYWeiHWuZ
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