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The multiple conformations observed from the single-particle EM analysis of the purified Fab7F38semaglutideGLP-1RGsNb35 complex most likely represent different agonist-bound ECD conformations, however some 2D classes are also compatible with the closed conformation observed in our inactive crystal structure (Supplementary Fig

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While gender was tested as a covariate in all analyses, the small sample size and low percentage of enrolled females did not allow us to investigate possible gender differences in endocrine outcomes after cannabis administration

DIRECTIONS FOR FUTURE RESEARCH The clinical use of GLP-1RAs and dual GIP/GLP-1RAs has risen sharply in recent years, driven by their proven efficacy in managing T2DM and obesity