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Consequently, a significant proportion of administered nanocarriers is prematurely sequestered and cleared by the reticuloendothelial system (RES)particularly the liver and spleensubstantially limiting the effective dose that reaches the osteosarcoma TME (69, 70)
On the other hand, substantial downregulation of GCLC, the ratelimiting enzyme of GSH synthesis, is consistent with our hypothesis that GSH synthesis is impaired in tumors
Psychological Stress and Mitochondria: A Systematic Review
High reactivity and powerful oxidant ONOO can cause nitration of protein tyrosine residues, resulting in mtDNA damage and membrane pore opening [53]