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Another rat study found that acute restraint stress can upregulate TLR4 gene expression in the frontal cortex by inducing gut microbiota translocation, while intervention with antibiotics or the TLR4 specific inhibitor TAK-242 effectively suppresses this process and reduces the accumulation of inflammatory and oxidative/nitrosative mediators (163)

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The greatest advantage physiologically appears to be from the IV push, but route of administration is customized to patient needs

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Biochim Biophys Acta 1486:7283

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& Meister, A

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