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Chris Twitty, Chief Scientific Officer of Skye, said, These data demonstrate for the first time how nimacimabs allosteric binding to the CB1 receptor is differentiated from the small molecules which bind to the receptors active orthosteric site

However, we noticed that many of the predicted mRNAs from H99 did not have ORFs as large as the predicted JEC21 ORFs

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For the IF-staining of the c-fos marker, brain sections (5 m) were incubated overnight at 4C in primary antibody (1:1,000, ab208942, abcam, UK) before being incubated with fluorophore-conjugated goat anti-mouse secondary antibody (1:1,000, ab150113, abcam, UK) for 30 min, then the CY3-Tyramide (1:500, G1223, Servicebio, China) was used for tyramide signal amplification