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Advances in biased agonism, region-selective targeting, and peripherally restricted analogs now offer potential strategies for selectively modulating central peptide systems without broad CNS disruption

Of note, Lani is currently in phase 3 clinical development for the treatment of liver fibrosis and MASH

The remaining data processing was performed using the cryoSPARC v2 workflow

Contraindications include: pregnancy and lactation, personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2 (MEN-2), history of pancreatitis, type 1 diabetes, severe gastrointestinal disease (including gastroparesis), and known hypersensitivity to GLP-1 analogues