This layered approach tackles hair loss from multiple angles and maximizes the chance for long-term success
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Whether this should be regarded as specific metabolic treatment, targeting only the metabolic alterations of the syndrome, is debatable, since the improvement in metabolic conditions, e.g., insulin resistance, would tenably have a positive impact also in gonadal function in women with PCOS
Vitamin D deficiency, already present in 35% to 40% of adults, worsens with reduced food intake
For example, the downregulation of specific genes, particularly those involved in neurotransmitter synthesis and metabolism, such as the serotonin transporter gene (SLC6A4) and BDNF, is closely linked to depression onset [364]