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In the recent past, several studies have revealed metal responsive genes and their genetic manipulations have suggested strategies to develop different crop varieties with improved stress tolerance and avoidance

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Strategies that deplete GSH, such as using inhibitors like BSO which is inhibitor of -glutamylcysteine synthetase (-GCS) , the rate-limiting enzyme in glutathione (GSH) synthesis or by combining prodrug activation with GSH depletion in nanosystems, have shown promise in overcoming MDR and improving chemotherapy effectiveness [72]

In addition, the supplementation of selenium, alone or together with vitamin E, did not show any benefits regarding the risk of prostate, lung, or colorectal cancers after 5.5 years of follow-up (86, 87)

For instance, the Central Drugs Standard Control Organization (CDSCO) in India has been approved to address conditions such as alcoholic fatty liver, alcoholic liver fibrosis, alcoholic liver cirrhosis, and alcoholic hepatitis[2]