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Eligibility criteria typically include BMI thresholds (most commonly 27+ with comorbidities or 30+ without), age (usually 18+), and absence of contraindications (pregnancy, certain cancer histories, severe GI disease)
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Investigators titrated the dose upward over several weeks to limit gastrointestinal effects, a pattern consistent with the wider incretin class
Xu K et al
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Although raised homocysteine levels might be partly due to a poor vitamin B 12 status, the latter was not related to risk of dementia or Alzheimer's disease in this study (73)
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