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The WD40 domains of COP1 b and COP1 d interact with DET1 in a manner similar to the COP1-DDD-Ube2e dimer (described below), while the RING dimers are in close proximity to Ube2e2 (Fig

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Yang F, Kosten TR (2019) Psychopharmacology: neuroimmune signaling in psychiatric disease-developing vaccines against abused drugs using toll-like receptor agonists