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Una vez que vence la patente, otros fabricantes pueden producir biosimilares (equivalentes a los genricos, pero para biolgicos), lo cual reduce los precios significativamente

et al., PNAS (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

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Diabetes 64(10):34063412 Cukierman-Yaffe T, Gerstein HC, Colhoun HM et al (2020) Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

When the research question specifically isolates these two mechanisms, adding GHK-Cu introduces confounding from its gene-expression and anti-inflammatory effects