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MT-II stimulates melanogenesis via MC1R on melanocytes darker pigmentation following short subcutaneous dosing. In the CNS, MT-II can trigger erections without sexual stimulation, pointing to central melanocortin circuitry (hypothalamic and spinal sites). Discovery & Research Milestones Discovery & Research Milestones Originated at the University of Arizona in the 1980s, where researchers were exploring sunless tanning agents. Built as a short, stable analog of -MSH, improving its half-life and activity compared to the natural hormone. Early studies tested Melanotan II in skin pigmentation disorders and sexual dysfunction, but it never achieved regulatory approval
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Proc Natl Acad Sci USA 104(9):32193224 Harrington LS et al (2008) Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells
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