Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning
For example, older people (because absorption declines with age) and those with gut-related conditions such as celiac disease and Crohns disease may struggle to absorb enough vitamin B12 to stave off symptoms of a deficiency, says Foxx
References Achilleos, K., Petrou, C., Nicolaidou, V., & Sarigiannis, Y
Vitamin B12 Injection FAQ's How quickly will I notice a difference after my B12 injection
Journal of Diabetes Research