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Any patient on any therapy can be monitored for general signals of harm

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38 This pain commonly presents as spontaneous burning sensations in the feet, and patients may also report positive sensory symptoms such as brush-evoked allodynia (pain from normally non-painful stimuli) and paresthesias, which are often accompanied by sensory loss, leading patients to describe the paradox of their feet being continuously painful yet insensate to touch

doi: 10.1124/pr.107.07109 175

Ashe P, Chlan-Fourney J, Juorio AV, Li XM