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What has changed is not the feasibility of developing drugs without complete biological knowledge, but the expectation that developers be transparent about what is and is not known, and that uncertainty be actively managed rather than minimized (ICH E9 guidance

On-going studies are required to further explore the biological significance of these findings, and the relevance of these findings to human phenotype and disease

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For example, gender may affect how the body processes the medication, with some studies showing different responses in men and women

Researchers exploring these options do so at their own informed discretion