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Comparative studies looking at dose-response on either compound separately should use the standalone preparations to control concentration independently

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doi: 10.1016/j.redox.2023.102855 73 HuangFWangQGuoFZhaoYJiLAnTet al

In another RCT ( n = 80), prolonged-release melatonin (PRM 2-mg) therapy showed a significant improvement in sleep hours and reduction in delirium episodes among hospitalized insomniac COVID-19 patients 668