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Plasma GLP-1 concentrations (pg/mL) were significantly decreased in cocaine-experienced rats versus yoked-saline controls following 21 days of self-administration (Fig 1B) and acute withdrawal (i.e., extinction day 1) (Fig 1C)

As a general framework: Want a single large dose with hydration or other IV ingredients, and don't mind clinic visits

In any case, our data could mean that in mouse cardiac studies, one can assume that any beneficial effects of dulaglutide in cardiac ischemia and reperfusion are not negatively affected by a positive chronotropic effect or positive inotropic effect of dulaglutide and are thus a useful model to study beneficial effects of GLP-1R stimulation of non-cardiomyocytes in the heart

But the medication can reduce weight and improve insulin sensitivity, thus improving the chances of pregnancy