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Intramuscular administration allows B12 to bypass hepatic metabolism and enter systemic circulation directly, which is why this route differs from oral supplementation

The higher vascularity of muscle can lead to a quicker rise in circulating concentrations, which might be advantageous in applications requiring a faster onset of action

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Keratolytics may help reduce a buildup of dead skin cells, and people can look for products containing any of the following ingredients: lactic acid AHA glycolic acid salicylic acid a retinoid, such as retinol, tretinoin, tazarotene, or adapalene urea In some cases, topical corticosteroids may help soften the bumps and reduce discoloration

doi: 10.1136/bmj.m2482 72