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Common cycling patterns include standard cycles of 8 weeks on followed by 4 weeks off, extended cycles of 12 weeks on followed by 6 weeks off for more aggressive protocols, and conservative cycles of 6 weeks on followed by 3 weeks off for those preferring a cautious approach

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Given the possibility that cimetidine may benefit a subset of patients without significant AEs in the context of a small total sample exposed to the drug (n=40, including the RCT), the lack of long-term follow-up data on sufficient numbers of patients, and its potential to interact with other drugs, oral cimetidine was designated as an Option